Gout accumulates which metabolic product?

• A. Urea
• B. Uric acid
• C. Creatinine
• D. Lactic acid

Answer: (B)

Gout centers on uric acid, the end product of purine breakdown. When uric acid accumulates, it can crystallize in joints and surrounding tissues, triggering the painful inflammatory attacks that define gout. Uric acid is produced from purine metabolism, filtered by the kidneys, and excreted in urine; excess production or reduced excretion leads to hyperuricemia and gout.

Urea, in contrast, is produced from amino acid degradation and is a major nitrogen waste; it tends to rise mainly in kidney dysfunction but isn’t what causes gout. Creatinine comes from muscle metabolism and serves as a kidney function marker, not a driver of gout. Lactic acid accumulates from anaerobic metabolism and is linked to different physiological states; it’s not the culprit in gout.