Absorption site for vitamin B12?

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Prepare for the National Association of Nutritional Professionals (NANP) Domain IV Test. Review flashcards and multiple choice questions with detailed explanations. Get exam-ready!

Multiple Choice

Absorption site for vitamin B12?

Explanation:
Vitamin B12 absorption relies on intrinsic factor and occurs in the distal ileum. After B12 is released from dietary proteins in the stomach, it binds intrinsic factor. The IF–B12 complex travels to the ileum, where enterocytes have receptors that specifically recognize this complex and transport it into the cells, with calcium playing a role in the uptake process. The duodenum and jejunum handle most other nutrient absorption, but they lack the specialized mechanism for IF–B12 uptake. The colon does not actively absorb B12. Therefore, the site of absorption for vitamin B12 is the ileum, specifically the distal ileum.

Vitamin B12 absorption relies on intrinsic factor and occurs in the distal ileum. After B12 is released from dietary proteins in the stomach, it binds intrinsic factor. The IF–B12 complex travels to the ileum, where enterocytes have receptors that specifically recognize this complex and transport it into the cells, with calcium playing a role in the uptake process. The duodenum and jejunum handle most other nutrient absorption, but they lack the specialized mechanism for IF–B12 uptake. The colon does not actively absorb B12. Therefore, the site of absorption for vitamin B12 is the ileum, specifically the distal ileum.

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